Larger trials will still, on average, overestimate effects,

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pandora jewellery Again, we showed an association with the size of the truncated trial: large overestimates were common when the total number of events was less than 200; smaller but important overestimates occurred with 200 to 500 events; and trials with over 500 events showed small overestimates.3The results of simulation studies and systematic surveys of truncated trials therefore show that when true underlying treatment effects are modest as is usually the case small trials that are stopped early with few events will result in large overestimates. Larger trials will still, on average, overestimate effects, and these overestimates may also lead to important spurious inferences. Uncritical belief in truncated trials will often, therefore, be misleading and sometimes very misleading.. pandora jewellery

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