Exposure to 5 ARI was quantified by the number of cumulatively

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pandora necklaces We adjusted the association between prostate cancer risk and 5 ARI exposure for covariates that were potential confounding factors including:Increased diagnostic activity driven by lower urinary tract symptoms as indicated by blocker use; and transurethral resection of the prostate or increased levels of prostate specific antigen, as indicated by biopsies.Comorbidity before date of diagnosis assessed by the Charlson comorbidity index, based on discharge diagnoses in the Swedish inpatient register before the date of diagnosis for the index caseSocioeconomic factors assessed by family status and highest level of education attained.Results were summarised with odds ratios and 95% confidence intervals.21 We calculated trend tests using the categories on an equidistant ordinal scale, and P values were two tailed. Exposure to 5 ARI was quantified by the number of cumulatively dispensed defined daily doses and first categorised into any use (one or more prescriptions dispensed) or no use (no prescriptions dispensed). Exposure was then separated according to the duration of defined daily doses (0 1, 1 2, 2 3, and >3 years).22 We analysed finasteride and dutasteride, the two available 5 ARIs, combined because their outcomes were virtually the same in two clinical trials.1 2 Because there was no reason to believe that an increasing exposure to blockers could prevent or induce prostate cancer, exposure was divided into any use or no use in the main analysis.Some men could have had elevated serum levels of prostate specific antigen or an abnormal digital examination, and concomitantly had lower urinary tract symptoms; therefore, they may have undergone an investigation leading to a prostate cancer diagnosis in parallel with the initiation of 5 ARI or blocker treatment for lower urinary tract symptoms. pandora necklaces

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